The goal of this study is to analyze the capacity of the International Biodiversity Regime (IBR) to resolve the problem of the biology diversity loss. Considering that regimes are effective when they serve to solve the problems that caused his creation, this exercise was based on the crossroad of two models of evaluation: the model pression-state-answer and the model of evaluation of the effectiveness of the environmental regimes. As the result, it is argued that is possible to give an instrumental vision to the Biodiversity Regime, in way, throught his degree of effectiveness, it is seen as an indicator of environmental sustainability. In this sense, using the exemplary case of the Mamirauá Sustainable Development Reserve, there was discussed the contribution of the different actors wrapped in the implementation of the IBR and in which measure the mechanisms of international cooperation and financing can favor institutional strengthening necessary to the Regime implementation. In the conclusion, it was observed that the IBR make practical the institutional diversified outline that contemplates administrative necessary flexibility for management and resources collectation in the solution of the biology diversity loss. His effectiveness, however, is straightly connected with a political process, where throught the dialog state actors and civil global society is possible to settle a continuated flow of experiences, between the local and the global, which in much contributes to the reduction of the biological diversity loss, enlarging the natural resources stocks and consequently, contributing to the promotion of the sustainable development.