The objective of this dissertation is two-fold: (i) to propose an evaluation model to assess incubated technology-based small and medium enterprises (SMEs) concerning the adoption of ISO 26000 guidelines; (ii) to validate the proposed model through a multiple case study on selected incubated technology-based SMEs. In the context of university incubators, it was assumed that these enterprises have the potential to contribute to the promotion of sustainable development, through socially and environmentally sustainable operations, and by generating new sustainable products and services. The research methodology encompasses bibliographical and documental review on research’s central themes, with an attempt to design a conceptual model that integrates the referred themes, within the perspective of future application in university incubators in Brazil. Additionally, a multiple case study was carried out, focusing on six selected SMEs. The main results can be summarized as follows: (i) an innovative evaluation model to assess incubated technology-based small and medium enterprises regarding the adoption of ISO 26000 guidelines; and (ii) a set of new indicators for selecting candidates and assessing performance of incubated enterprises aligned to ISO 26000 guidelines.